DAVID Bioinformatics 6.8
The Database for Annotation, Visualization and Integrated Discovery
DAVID Bioinformatics Resources 6.8
Laboratory of Human Retrovirology and Immunoinformatics (LHRI)

*** Welcome to DAVID 6.8 ***
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release Release & Version Information

DAVID 2021 (Dec. 2021)
  • The DAVID Gene system was rebuilt by combining NCBI's Entrez Gene database and Uniprot in order to recover the loss of a large number of Prokaryotes due to the effect of the NCBI Prokaryotic RefSeq Genome Re-annotation Project.
  • The DAVID Knowledgebase was updated, and along with the new DAVID Gene system, greatly improved overall annotation coverage and the number of supported taxonomies with infrastructure added to facilitate quarterly updates.
  • New annotations were added to the Knowledgebase including small molecule-gene interaction information from PubChem, drug-gene interaction information from DrugBank, tissue expression information from the Human Protein Atlas (HPA), disease information from DisGeNET, and pathways from WikiPathways and PathBank.
  • Uniprot Keyword annotation was split into eight subgroups with four assigned to the original "Functional" category and the remaining four assigned to specific categories: Disease, Protein interactions and Tissue Expression.
  • Since gene symbol is the top uploaded identifier and ambiguous between species, we added a species selection parameter to increase the efficiency of the list upload process.
  • Updated documentation
  • Uniprot Comment annotation was split into categories and added to the gene report along with Entrez Gene, Ensembl Gene, Uniprot, PubChem and DrugBank

DAVID 6.8 (Oct. 2016)
  • The DAVID Knowledgebase completely rebuilt.
  • Entrez Gene integrated as the central identifier to allow for more timely updates while still incorporating Ensembl and Uniprot as integral data sources.
  • New GO category (GO Direct) provides GO mappings directly annotated by the source database (no parent terms included)
  • New annotation categories
  • New list identifier systems added for list uploading and conversion
  • A few bugs fixed

DAVID 6.7 (Jan. 2010)
  • The DAVID Knowledgebase completely rebuilt, including the central DAVID id system
  • Ensembl Gene included as an integral data source
  • DAVID engine completely rebuilt to facilitate future updates and development
  • New GO category (GO FAT) filters out very broad GO terms based on a measured specificity of each term (not level-specificity)
  • New annotation categories
  • New list identifier systems added for list uploading and conversion
  • Automatic list naming based on uploaded file name
  • Ability to upload expression/other values (some display, but otherwise not used in the analysis at this point)
  • A few bugs fixed

DAVID 2008 (April 2008)
  • The DAVID Knowledgebase available for downloads (updated March 2008)
  • Some new annotation categories
  • Ensembl Gene and Illumina added for list uploading
  • A few bugs fixed

DAVID 2007 (Jan. 2007)
  • The DAVID Knowledgebase available for downloads
  • Some new annotation categories: Tissue expression (GNP,CGAP,UNIGENE EST); NCI thesaurus; Reactome; Pather; etc.
  • The DAVID API Services for linking to DAVID from other websites
  • A couple of new funtionalities to be incoporated in the summer time
  • A few bugs fixed

DAVID 2006 (May 2006)
  • New function in functional annotation tool: Term functional classification
  • Added pre-built Affy gene background
  • Allowed user loaded customized gene background
  • Re-designed DAVID web layout from multiple frames to single frame
  • Re-designed key calculation engines from Oracle database query to memory data query
  • Updated all data contents of DAVID knowledgebase
  • Added new tissue expression data
  • Added easy sort function to most of result pages
  • Moved data download link/buttons to result pages
  • Launched DAVID Forum to efficiently share experiences among DAVID community
  • A few bugs fixed

DAVID 2.1 (Aug. 2005)
  • New tool: Functional Classification
  • New function: fuzzy heat map
  • New function: 2-D heat map
  • A few bugs fixed

DAVID 2.1 Alpha (Feb. 2005)
  • DAVID expanded from single "Functional Annotation Tool" to multiple tools (see below) and new home page designed to host multiple tool sets
  • New tool: DAVID Gene Accession Conversion
  • New tool: NIAID Pathogen Genome Browser
  • New function in functional annotation tool: Term-term linear search
  • New function functional annotation tool: Gene-gene linear search
  • New summary options in functional annotation: advanced and standard
  • New summary layout in functional annotation: expandable tree structure
  • Optimized oracle query to speed up the summary page in functional annotation
  • Added Unigene Database to increase the coverage of GI
  • Updated most of the data contents for DAVID Knowledgebase

DAVID 2.0 (Nov. 2004)
  • Tuned up SQL query to speed up search
  • New function: "Pathway Mapping"  to allocate given genes on static pathway pictures
  • Fixed some bugs

DAVID 2.0 Alpha (Sep. 2004)
  • New annotation contents:  much more annotation resources integrated to DAVID knowledgebase.
  • New integration solution: DAVID Gene Concept to replace LocusLink-centric structure
  • Updated most of the existing data contents for DAVID knowledgebase
  • Developed completely new oracle schemas to hold DAVID knowledagebase
  • Developed completely new interfaces
  • Developed "Enhanced Function" for homologue comparisons
  • Introduced "DAVID gene ID" as an internal unqiue gene cluster ID
  • Introduced "DAVID Chart Report"
  • Introduced "DAVID Table Report"
  • Introduced "DAVID Gene Report"
  • Introduced "Export Function" to save selected annotation results
  • Developed "Gene List Manager"
  • Developed "Create Sublist Function"

DAVID 1.0 (June 2003)
  • Fisher Exact test for gene-enrichment analysis
  • DAVID Knowledgebase linked by LocusLink

 Please cite Nature Protocols 2009; 4(1):44 & Nucleic Acids Res. 2009;37(1):1 within any publication that makes use of any methods inspired by DAVID.
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